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In areas of DNA where RNA binds to one of the DNA threads in such a way that the complementary DNA thread becomes the sole thread-R loop structure. The DNA stability will change if RNA is chemically modified by m6A.
In areas of DNA where RNA binds to one of the DNA threads in such a way that the complementary DNA thread becomes the sole thread (R-loop structures), the DNA stability will change if RNA is chemically modified by m6A.
“Several research groups are now working together to study what effect this can have on the DNA molecule. We already know that R-loop areas are associated with sequences of DNA containing active genes and that this can lead to chromosomal breakage and the loss of genetic information,” explains Klungland. –